Detalhe da pesquisa
1.
Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia.
Blood
; 135(8): 547-557, 2020 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31899794
2.
Erythroferrone inhibits the induction of hepcidin by BMP6.
Blood
; 132(14): 1473-1477, 2018 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30097509
3.
A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
J Biol Chem
; 291(3): 1267-76, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26515064
4.
Characterization of binding mode of action of a blocking anti-platelet-derived growth factor (PDGF)-B monoclonal antibody, MOR8457, reveals conformational flexibility and avidity needed for PDGF-BB to bind PDGF receptor-ß.
Biochemistry
; 54(10): 1918-29, 2015 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25707433
5.
An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition.
J Biol Chem
; 287(53): 44425-34, 2012 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23148212
6.
LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model.
Proc Natl Acad Sci U S A
; 107(8): 3734-9, 2010 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20133709
7.
Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3.
Sci Rep
; 13(1): 13408, 2023 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37591971
8.
Estrogen receptor beta agonism increases survival in experimentally induced sepsis and ameliorates the genomic sepsis signature: a pharmacogenomic study.
J Infect Dis
; 201(8): 1250-7, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20205571
9.
Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation.
Sci Rep
; 11(1): 8921, 2021 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33903632
10.
Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors.
MAbs
; 13(1): 1850395, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33459147
11.
Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo.
J Biol Chem
; 284(40): 27352-9, 2009 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-19657146
12.
Pharmacogenomic, physiological, and biochemical investigations on safety and efficacy biomarkers associated with the peroxisome proliferator-activated receptor-gamma activator rosiglitazone in rodents: a translational medicine investigation.
J Pharmacol Exp Ther
; 334(3): 820-9, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20519551
13.
Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood.
J Transl Med
; 8: 51, 2010 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20509950
14.
Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody.
J Transl Med
; 8: 50, 2010 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20504348
15.
A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers.
Clin Cancer Res
; 26(9): 2188-2202, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31996389
16.
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse.
J Lipid Res
; 50(12): 2358-70, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19318684
17.
Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration.
Mol Cell Endocrinol
; 302(1): 26-32, 2009 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19356623
18.
A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy.
Ann Neurol
; 63(5): 561-71, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18335515
19.
Use of ex vivo systems for biomarker discovery.
Curr Opin Pharmacol
; 8(5): 647-53, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18771752
20.
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci
; 17(1): 16-21, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18042673